While social media use provides opportunities for nurses to connect with others, both on a personal and professional level, nurses must also understand the risks that are associated with it. Inappropriate and unprofessional use of social media may lead to findings of unprofessional conduct resulting in disciplinary action. A nursing regulatory body may deem any activity on social media to be unprofessional if it harms the integrity of the client, person, employer, another health professional, colleague, or organization. This document provides guidelines that support critical thinking and decision-making in the responsible use of social media. It is not intended to cover every social media and social networking situation. Understanding and applying the guidelines while using social media will help nurses maintain social media competence and professionalism.